Chemical and Drug Induced Liver Injury

MeSH ID: D056486
Disease: Chemical and Drug Induced Liver Injury
MeSH Category: Digestive System Diseases, Chemically-Induced Disorders
MeSH Sub Category: Drug-Related Side Effects And Adverse Reactions, Poisoning, Liver Diseases


Spices/Herbs associated with Chemical And Drug Induced Liver Injury

Spice/Herb Name Association Details
Garlic 26, 2
Associations of Garlic with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
26507778 Garlic Aged Garlic Extract Enhances Heme Oxy... Nutrition Research (New York, N.Y.) 2016
27790139 Garlic Garlic And Resveratrol Attenuate Diab... Frontiers In Pharmacology 2016
27393449 Garlic Therapeutic Effect Of Aqueous Extract... Pakistan Journal Of Pharmaceutical Sc... 2016
25062976 Garlic Diallyl Trisulfide Ameliorates Arseni... Human & Experimental Toxicology 2015
24711843 Garlic The Effect Of Garcin® In Preventing A... Iranian Journal Of Pharmaceutical Res... 2014
23730560 Garlic Modulatory Effects Of Dietary Inclusi... Asian Pacific Journal Of Tropical Bio... 2013
23861709 Garlic Garlic-Derived S-Allylmercaptocystein... Evidence-Based Complementary And Alte... 2013
22280552 Garlic Beneficial Effect Of Garlic On D-Gala... Allergologia Et Immunopathologia 2012
22119904 Garlic Dietary Agents In The Prevention Of A... Food & Function 2012
21681437 Garlic S-Allylmercaptocysteine Reduces Carbo... European Journal Of Nutrition 2012
24725925 Garlic Garlic In Health And Disease. Nutrition Research Reviews 2011
20004152 Garlic Garlic Extract Prevents Ccl(4)-Induce... Digestive And Liver Disease : Officia... 2010
20635693 Garlic [Protective Effect Of Garlic Oil Give... Zhonghua Lao Dong Wei Sheng Zhi Ye Bi... 2010
19742242 Garlic Protective Effects Of Garlic And Sily... International Journal Of Biological S... 2009
19082532 Garlic Hepatoprotective Potentials Of Onion ... Biological Trace Element Research 2009
19298201 Garlic Ethanol Extract Of Allium Sativum Att... Journal Of Medicinal Food 2009
17512651 Garlic Garlic Oil Ameliorates Ferric Nitrilo... Food And Chemical Toxicology : An Int... 2007
17046167 Garlic A Postulated Role Of Garlic Organosul... Medical Hypotheses 2007
16489682 Garlic Effect Of Garlic On Isoniazid And Rif... World Journal Of Gastroenterology 2006
16910057 Garlic Garlic Hepatotoxicity: Safe Dose Of G... Tropical Gastroenterology : Official ... 2006
17201643 Garlic Tropical Green Leafy Vegetables Preve... Journal Of Medicinal Food 2006
16000231 Garlic Modulation Of Cytochrome P450 Enzymes... Food And Chemical Toxicology : An Int... 2005
11791733 Garlic Protective Effect Of Ajoene On Acetam... Bioscience, Biotechnology, And Bioche... 2001
10100508 Garlic Mechanisms Of The Preventive Properti... Research Communications In Molecular ... 1998
9310267 Garlic Modulatory Potential Of Smokeless Tob... Cancer Letters 1997
8560468 Garlic Protective Effects Of Garlic And Rela... Toxicology And Applied Pharmacology 1996
28543822 Garlic Good For The Lung But Bad For The Liv... Journal Of Clinical Pharmacy And Ther... 2017
22512600 Garlic Grape Seed And Skin Extract Mitigates... Canadian Journal Of Physiology And Ph... 2012


Linked Phytochemicals
PubChem ID Common Name Explore
11617 Diallyl Sulfide
62434 Allyl Methyl Disulfide
16590 Diallyl Disulfide
16315 Diallyl Trisulfide
Turmeric 22, 1
Associations of Turmeric with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
28336172 Turmeric Curcuma Longa Linn. Extract And Curcu... Experimental And Toxicologic Patholog... 2017
28675957 Turmeric Protective Mechanism Of Turmeric (Cur... Pharmaceutical Biology 2017
26631570 Turmeric Pharmacodynamics Study Of Zedoary Tur... Artificial Cells, Nanomedicine, And B... 2016
27561811 Turmeric Turmeric Extract And Its Active Compo... Bmc Complementary And Alternative Med... 2016
27356682 Turmeric Curcumin: A Polyphenol With Molecular... Asian Pacific Journal Of Cancer Preve... 2016
26199067 Turmeric Pre-Administration Of Turmeric Preven... Bmc Complementary And Alternative Med... 2015
24945581 Turmeric A Pparγ, Nf-Κb And Ampk-Dependent Mec... Molecules (Basel, Switzerland) 2014
23387246 Turmeric Effects Of Curcumin On The Gastric Em... Indian Journal Of Physiology And Phar... 2012
22452372 Turmeric Curcumin Ameliorates Hepatic Fibrosis... British Journal Of Pharmacology 2012
22449800 Turmeric Curcumin Eliminates The Inhibitory Ef... Laboratory Investigation; A Journal O... 2012
22692588 Turmeric Curcumin Ameliorates Mitochondrial Dy... International Journal Of Molecular Me... 2012
22119904 Turmeric Dietary Agents In The Prevention Of A... Food & Function 2012
20932240 Turmeric Conundrum And Therapeutic Potential O... Critical Reviews In Therapeutic Drug ... 2010
20332524 Turmeric Curcumin Improves Sclerosing Cholangi... Gut 2010
19577913 Turmeric Effects Of A Turmeric Extract (Curcum... Phytomedicine : International Journal... 2009
19459743 Turmeric The Role Of Curcuma Longa Against Dox... Journal Of Medicinal Food 2009
18221818 Turmeric Curcumin Inhibits Glucose Production ... Diabetes Research And Clinical Practice 2008
17569218 Turmeric Immunomodulation By Curcumin. Advances In Experimental Medicine And... 2007
17569208 Turmeric Modulation Of Transcription Factors B... Advances In Experimental Medicine And... 2007
17355460 Turmeric Prevention Of Liver Cirrhosis In Rats... Liver International : Official Journa... 2007
14764309 Turmeric The Curcuma Antioxidants: Pharmacolog... Archives Of Gerontology And Geriatrics 2002
9782784 Turmeric Subchronic Oral Hepatotoxicity Of Tur... Indian Journal Of Experimental Biology 1998
9704820 Turmeric Subchronic Oral Toxicity Of Turmeric ... Toxicology Letters 1998


Linked Phytochemicals
PubChem ID Common Name Explore
969516 Curcumin
Liquorice 20, 0
Associations of Liquorice with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
28572827 Liquorice Protective Effect Of 18<I>Β</I>-Glycy... Evidence-Based Complementary And Alte... 2017
27255442 Liquorice Oxidative Inactivation Of Liver Mitoc... Phytotherapy Research : Ptr 2016
26801973 Liquorice Hepatoprotective Effect Of Licorice, ... Bmc Complementary And Alternative Med... 2016
26841168 Liquorice Bioactive Constituents Of Glycyrrhiza... Journal Of Natural Products 2016
26915867 Liquorice Inhibition Of High Mobility Group Box... Transplantation Proceedings 2016
26205049 Liquorice Anti-Inflammatory Activities Of Licor... Molecules (Basel, Switzerland) 2015
26697674 Liquorice Progress On Mechanism Of Tripterygium... Zhongguo Zhong Yao Za Zhi = Zhongguo ... 2015
23415946 Liquorice Systems Approaches And Polypharmacolo... Journal Of Ethnopharmacology 2013
23771023 Liquorice Glycyrrhizin Represses Total Parenter... International Journal Of Molecular Sc... 2013
22982774 Liquorice Pregnane X Receptor Mediated-Transcri... Chemico-Biological Interactions 2012
22499717 Liquorice Pharmacological Study Of The Effect O... Journal Of Complementary & Integrativ... 2011
21972810 Liquorice Glycyrrhetinic Acid Extracted From Gl... Journal Of Asian Natural Products Res... 2011
20393696 Liquorice Effect Of Glycyrrhizin On The Activit... European Journal Of Clinical Pharmaco... 2010
19897483 Liquorice 18beta-Glycyrrhetinic Acid Ameliorate... The Journal Of Biological Chemistry 2010
18671195 Liquorice The Disposition Of Diammonium Glycyrr... Planta Medica 2008
16718735 Liquorice Azathioprine Hepatotoxicity And The P... Phytotherapy Research : Ptr 2006
17030102 Liquorice Isoniazid-Induced Hepatotoxicity In R... Toxicology Letters 2006
16797510 Liquorice Acetaminophen-Induced Hepatotoxicity ... Chemico-Biological Interactions 2006
15142335 Liquorice Pharmaceutical Evaluation Of Liquoric... The Journal Of Pharmacy And Pharmacology 2004
8783808 Liquorice Therapeutic Basis Of Glycyrrhizin On ... Antiviral Research 1996
No negative associations were obtained for Liquorice with Chemical and Drug Induced Liver Injury.


Linked Phytochemicals
PubChem ID Common Name Explore
5280805 Rutin
638278 Isoliquiritigenin
3495 Glycyrrizin
5280961 Genistein
667495 (2r)-Naringenin
Ginger 15, 0
Associations of Ginger with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
27356682 Ginger Curcumin: A Polyphenol With Molecular... Asian Pacific Journal Of Cancer Preve... 2016
26948519 Ginger Ginger For Prevention Of Antitubercul... Phytotherapy Research : Ptr 2016
27393449 Ginger Therapeutic Effect Of Aqueous Extract... Pakistan Journal Of Pharmaceutical Sc... 2016
26551763 Ginger Protective Effect Of Zingiber Officin... Pharmacology 2016
26228533 Ginger Gingerols And Shogaols: Important Nut... Phytochemistry 2015
26548077 Ginger Ginger Extract Ameliorates Phosphamid... Indian Journal Of Experimental Biology 2015
25866718 Ginger Ginger From Ancient Times To The New ... Jundishapur Journal Of Natural Pharma... 2015
24945581 Ginger A Pparγ, Nf-Κb And Ampk-Dependent Mec... Molecules (Basel, Switzerland) 2014
25068142 Ginger Effect Of Hydroalcoholic Extract Of G... Avicenna Journal Of Phytomedicine 2014
23927622 Ginger Hepatoprotective, Antioxidant, And Am... Journal Of Dietary Supplements 2013
21902812 Ginger Attenuation Of Liver Pro-Inflammatory... Basic & Clinical Pharmacology & Toxic... 2012
20872761 Ginger Ginger Ingredients Inhibit The Develo... Biofactors (Oxford, England) 2010
18182172 Ginger Ethanol Toxicity: Rehabilitation Of H... Fitoterapia 2008
17637489 Ginger Zingiber Officinale Roscoe Prevents A... Food And Chemical Toxicology : An Int... 2007
16941609 Ginger Protective Effects Of Zingiber Offici... Phytotherapy Research : Ptr 2006
No negative associations were obtained for Ginger with Chemical and Drug Induced Liver Injury.


Linked Phytochemicals
PubChem ID Common Name Explore
5280343 Quercetin
101977 D-Citronellol
3314 Eugenol
72276 (-)-Epicatechin
222284 Beta-Sitosterol
689043 Caffeic Acid
Sesame 12, 0
Associations of Sesame with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
27619544 Sesame Daily Sesame Oil Supplementation Miti... The Journal Of Nutritional Biochemistry 2016
23744838 Sesame Beneficial Effect Of Sesame Oil On He... Jpen. Journal Of Parenteral And Enter... 2014
22915054 Sesame Investigation Of The Hepatoprotective... The Journal Of Membrane Biology 2013
22443367 Sesame Comparative Potential Therapeutic Eff... Journal Of Veterinary Internal Medicine 2012
20852187 Sesame Effects Of Sesame Oil Against After T... Jpen. Journal Of Parenteral And Enter... 2010
18443139 Sesame Sesame Oil Does Not Show Accumulative... Jpen. Journal Of Parenteral And Enter... 2008
17224796 Sesame Sesame Oil Attenuates Cisplatin-Induc... Shock (Augusta, Ga.) 2007
17304116 Sesame Sesame Oil Protects Against Lead-Plus... Shock (Augusta, Ga.) 2007
17117140 Sesame Sesame Oil Attenuates Acute Iron-Indu... Shock (Augusta, Ga.) 2006
15087824 Sesame Effects Of Sesame Oil On Oxidative St... Shock (Augusta, Ga.) 2004
15036764 Sesame Parenteral Sesame Oil Attenuates Oxid... Toxicology 2004
14707583 Sesame Sesame Oil Protects Against Lipopolys... Critical Care Medicine 2004
No negative associations were obtained for Sesame with Chemical and Drug Induced Liver Injury.


Linked Phytochemicals
PubChem ID Common Name Explore
68289 Sesamol
72307 Sesamin
Black Cumin 9, 1
Associations of Black Cumin with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
26826824 Black Cumin Effect Of Lipid Extracts Of Nigella S... Pakistan Journal Of Pharmaceutical Sc... 2016
27814700 Black Cumin The Hepatoprotective Activity Of Oliv... Bmc Complementary And Alternative Med... 2016
25675711 Black Cumin Therapeutic Efficacy Of Nigella Sativ... Indian Journal Of Experimental Biology 2015
25809628 Black Cumin Therapeutic Value Of Black Seed Oil I... Infectious Disorders Drug Targets 2015
25053547 Black Cumin Protective Effect Of Nigella Sativa O... Chinese Journal Of Natural Medicines 2014
22539463 Black Cumin Cadmium-Induced Hepatotoxicity And It... Journal Of Biochemical And Molecular ... 2012
15154284 Black Cumin The Effect Of Nigella Sativa Oil On G... The American Journal Of Chinese Medicine 2004
14696675 Black Cumin Protective Effect Of Nigella Sativa S... The American Journal Of Chinese Medicine 2003
11848252 Black Cumin Effect Of Nigella Sativa On Glucose C... Journal Of Veterinary Medicine. A, Ph... 2001
16076084 Black Cumin An Investigation On Ld50 And Subacute... Die Pharmazie 2005


Linked Phytochemicals
PubChem ID Common Name Explore
5280934 Linolenic Acid
10281 Thymoquinone
101977 D-Citronellol
Jiaogulan 7, 0
Associations of Jiaogulan with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
27708693 Jiaogulan Anti-Cancer Effects Of <I>Gynostemma ... Chinese Medicine 2016
24940444 Jiaogulan Gypenoside Attenuates Hepatic Ischemi... Experimental And Therapeutic Medicine 2014
22516894 Jiaogulan Preconditioning Of Brain Slices Again... Phytomedicine : International Journal... 2012
19699789 Jiaogulan The Inhibitory Effect Of Gynostemma P... Journal Of Ethnopharmacology 2009
18372131 Jiaogulan The Molecular Mechanism Of Gypenoside... Journal Of Ethnopharmacology 2008
18468406 Jiaogulan Gypenosides Induced G0/G1 Arrest Via ... In Vivo (Athens, Greece) 2008
10794120 Jiaogulan Antioxidant And Hepatoprotective Effe... The American Journal Of Chinese Medicine 2000
No negative associations were obtained for Jiaogulan with Chemical and Drug Induced Liver Injury.


Linked Phytochemicals
PubChem ID Common Name Explore
5280805 Rutin
Fenugreek 6, 0
Associations of Fenugreek with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
26612737 Fenugreek Ethanolic Extract Of Trigonella Foenu... Cellular And Molecular Biology (Noisy... 2015
24600306 Fenugreek Protective Effect Of Trigonella Foenu... Saudi Journal Of Biological Sciences 2014
23363543 Fenugreek Fenugreek Seeds, A Hepatoprotector Fo... Bmc Veterinary Research 2013
22082829 Fenugreek Effect Of Fenugreek Seed Extract On A... Toxicology And Industrial Health 2012
17484288 Fenugreek Fenugreek (Trigonella Foenum Graecum)... Die Pharmazie 2007
16574673 Fenugreek Fenugreek (Trigonella Foenum Graecum)... Alcohol And Alcoholism (Oxford, Oxfor... 2006
No negative associations were obtained for Fenugreek with Chemical and Drug Induced Liver Injury.


Linked Phytochemicals
PubChem ID Common Name Explore
5280343 Quercetin
5280805 Rutin
5281654 Isorhamnetin
689043 Caffeic Acid
667495 (2r)-Naringenin
Ginkgo 5, 1
Associations of Ginkgo with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
26759700 Ginkgo Pxr Mediated Protection Against Liver... Biomolecules & Therapeutics 2016
24472344 Ginkgo Hepatoprotective Effect Of Ginkgo Bil... Toxicon : Official Journal Of The Int... 2014
20136453 Ginkgo Protective Role Of Ginkgo Biloba Agai... Journal Of Medicinal Food 2010
17154234 Ginkgo Ginkgo Biloba Extract Protects Agains... Phytotherapy Research : Ptr 2007
17105595 Ginkgo Effects Of Ginkgo Biloba Extract On C... Liver International : Official Journa... 2006
20141330 Ginkgo Ginkgo Biloba Extract Induces Gene Ex... Omics : A Journal Of Integrative Biology 2010


Linked Phytochemicals
PubChem ID Common Name Explore
5280805 Rutin
6137 L-Methionine
72276 (-)-Epicatechin
5281654 Isorhamnetin
222284 Beta-Sitosterol
72307 Sesamin
Rosemary 6, 0
Associations of Rosemary with Chemical and Drug Induced Liver Injury
PMID Spice Title Journal Year
26828825 Rosemary Efficacy Of Rosmarinus Officinalis Le... Pharmaceutical Biology 2016
27823621 Rosemary Rosmarinic Acid Stimulates Liver Rege... Phytomedicine : International Journal... 2016
25737646 Rosemary Influence Of Olive And Rosemary Leave... Saudi Journal Of Biological Sciences 2015
17907303 Rosemary Hepatic Abscess Secondary To A Rosema... World Journal Of Gastroenterology 2007
12065145 Rosemary Evaluation Of The Effectiveness Of Ro... Journal Of Ethnopharmacology 2002
10641130 Rosemary Pharmacology Of Rosemary (Rosmarinus ... Indian Journal Of Experimental Biology 1999
No negative associations were obtained for Rosemary with Chemical and Drug Induced Liver Injury.


Linked Phytochemicals
PubChem ID Common Name Explore
5280343 Quercetin
5280805 Rutin
72281 Hesperetin
442428 Naringin
72276 (-)-Epicatechin
5281654 Isorhamnetin
689043 Caffeic Acid
667495 (2r)-Naringenin
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Phytochemicals linked to Chemical And Drug Induced Liver Injury


PubChem ID Common Name Explore References
222284 BETA-SITOSTEROL References
72281 hesperetin References
6137 L-methionine References
442428 naringin References
65064 (-)-Epigallocatechin gallate References
5280805 RUTIN References
180 acetone References
11617 DIALLYL SULFIDE References
689043 caffeic acid References
6918774 Corosolic acid References
68077 Tangeretin References
10621 hesperidin References
2353 berberine References
68289 Sesamol References
101977 D-Citronellol References
16315 Diallyl trisulfide References
5280343 quercetin References
3314 eugenol References
16590 DIALLYL DISULFIDE References
5281605 baicalein References
3495 Glycyrrizin References
638024 piperine References
6029 uridine References
667495 (2R)-naringenin References
323 coumarin References
785 hydroquinone References
4114 methoxsalen References
5280489 beta-carotene References
5280961 genistein References
638278 isoliquiritigenin References
637775 SINAPIC ACID References
5281654 Isorhamnetin References
10281 Thymoquinone References
936 nicotinamide References
5280934 linolenic acid References
72276 (-)-Epicatechin References
62434 ALLYL METHYL DISULFIDE References
114777 Theaflavin References
72307 sesamin References
5320351 Artemetin References
969516 curcumin References
64945 Ursolic acid References
5281613 diosmin References
10494 OLEANOLIC ACID References
5368396 Lutein References
1794427 CHLOROGENIC ACID References
5281643 Hyperoside References